SPIDR

Across TCGA cell cohorts, SPIDR mutation is significantly associated with the RNA expression of many other genes, with 22 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SPIDR-associated genes across cancer lineages are OR2AK2, CCDC140, and OR2L13. Each is linked with SPIDR in more than 1 cancer types. Because this analysis shows association rather than direction, both SPIDR-to-partner and partner-to-SPIDR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2AK2 grouped by SPIDR-low versus SPIDR-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPIDR→partner) and Y-score (partner→SPIDR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR2AK2 →	+0.014	+3.700	<.001	.009	3	2
LUNG_NSCLC_LUAD	CCDC140 →	+0.145	+4.212	.005	.007	3	1
LUNG_NSCLC_LUAD	OR2L13 →	+0.056	+4.212	<.001	.007	3	1
LARGE_INTESTINE	HPGDS →	+0.024	+3.772	.002	.003	3	1
LARGE_INTESTINE	BMP10 →	+0.021	+3.297	<.001	.002	3	1
LARGE_INTESTINE	TBC1D21 →	+0.008	+3.700	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

OR2AK2 by SPIDR expression — LARGE_INTESTINE

Explore this box plot interactively →