SPIDR

Across TCGA pan-cancer cohorts, SPIDR RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of SPIDR’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where SPIDR RNA is repressed in tumor relative to normal tissue. In most cancer types SPIDR is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, THCA, and COAD are the cancer types where SPIDR tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SPIDR RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−1.705	<.001	8	view →
THCA	Male	III,IV	−0.465	.005	7	view →
COAD	Female	All	+0.640	<.001	6	view →
LUAD	Female	II,III,IV	−0.575	<.001	6	view →
CHOL	All	All	+1.154	<.001	5	view →
HNSC	All	All	+0.452	.002	5	view →
STAD	Male	II,III,IV	+0.748	.006	4	view →
KIRC	All	All	+0.319	<.001	4	view →
READ	All	III,IV	+0.599	.045	2	view →
ESCA	Male	All	+0.586	.032	2	view →
BRCA	All	IV	−0.189	.047	2	view →
LIHC	Male	II,III,IV	+0.526	.034	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

SPIDR–KICH

Open the KICH breakdown →