Across TCGA cell cohorts, SPG7 mutation is significantly associated with the RNA expression of many other genes, with 582 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SPG7-associated genes across cancer lineages are RPL10L, IL31, and OR2F1. Each is linked with SPG7 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPG7-to-partner and partner-to-SPG7 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPG7→partner) and Y-score (partner→SPG7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	RPL10L →	+0.184	+3.906	<.001	.005	3	2
BREAST	IL31 →	+0.017	+3.672	<.001	.006	3	2
BREAST	OR2F1 →	+0.145	+3.758	<.001	.007	3	2
BLOOD_Leukemia	OR5B12 →	+0.036	+4.189	<.001	<.001	3	2
BLOOD_Leukemia	TMEM213 →	+0.066	+3.491	<.001	.001	3	2
LARGE_INTESTINE	PRDM16 →	+0.836	+3.628	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 582 associations by consensus.

Exploration

SPG7 survival (RNA) · tumor vs normal (RNA) · all SPG7 data types