SPDYE9

Q-omics provides the consensus-scored SPDYE9 profile across patient tissues and cancer cell-line models. SPDYE9 expression is associated with patient survival in 8 of 34 cancer types, with the highest sampling consensus in THCA. Additionally, SPDYE9 RNA expression shows 4,195 significant pathway-activity associations, with the highest sampling consensus in ESCA. Together, these results highlight THCA, and ESCA as cancer lineages where SPDYE9 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.

Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.

Survival associations

This table summarizes SPDYE9 survival associations across molecular data types. SPDYE9 RNA expression shows survival associations in the most cancer types (8). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.

SPDYE9 data type	Survival analysis	Lineage consensus	Lineage of highest sampling consensus
RNA	Kaplan–Meier	8	THCA (75)	view →

This table ranks reproducible SPDYE9 RNA expression–survival associations across cancer types. High SPDYE9 expression shows unfavorable associations in THCA, BLCA, UVM, ESCA, GBM and UCS. The THCA Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify THCA as the clearest survival context for SPDYE9 RNA expression.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THCA	OS	Tertile	III,IV	0.112	0.858	<.001	75	view →
BLCA	DFS	Tertile	III,IV	0.111	0.575	<.001	72	view →
UVM	OS	Tertile	III,IV	0.037	0.815	<.001	63	view →
ESCA	OS	Tertile	IV	0.135	0.568	.031	36	view →
GBM	OS	Tertile	All	0.070	0.413	.001	27	view →
UCS	DFS	Tertile	All	0.136	0.523	.034	18	view →

Pink = unfavorable, green = favorable. all 8 lineages →

SPDYE9-THCA (OS)

Explore this curve interactively →