SPDYE9

Across TCGA pan-cancer cohorts, SPDYE9 RNA is linked to patient survival in 8 of 34 cancer types, making it the most broadly survival-associated SPDYE9 data layer.

The strongest signal is observed in thyroid carcinoma (THCA), where higher SPDYE9 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SPDYE9 expression acts as an unfavorable survival marker.

THCA, BLCA, and UVM are the cancer types where SPDYE9 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THCA	OS	Tertile	III,IV	0.112	0.858	<.001	75	view →
BLCA	DFS	Tertile	III,IV	0.111	0.575	<.001	72	view →
UVM	OS	Tertile	III,IV	0.037	0.815	<.001	63	view →
ESCA	OS	Tertile	IV	0.135	0.568	.031	36	view →
GBM	OS	Tertile	All	0.070	0.413	.001	27	view →
UCS	DFS	Tertile	All	0.136	0.523	.034	18	view →
KIRP	DFS	Tertile	All	0.218	0.771	.029	18	view →
BRCA	OS	Tertile	III,IV	0.134	0.552	.002	15	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

SPDYE9–THCA (OS)

Open the THCA breakdown →