SPCS3-AS1

Across TCGA pan-cancer cohorts, SPCS3-AS1 RNA is linked to patient survival in 12 of 34 cancer types, making it the most broadly survival-associated SPCS3-AS1 data layer.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher SPCS3-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SPCS3-AS1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and ESCA show a favorable association.

LUSC, MESO, and HNSC are the cancer types where SPCS3-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	OS	Tertile	All	0.725	0.827	.007	30	view →
MESO	DFS	Tertile	All	0.113	0.485	.003	27	view →
HNSC	DFS	Tertile	All	0.844	0.682	.020	18	view →
ACC	OS	Tertile	III,IV	0.189	0.757	<.001	18	view →
KICH	DFS	Quartile	II,III,IV	0.223	0.874	.005	11	view →
STAD	DFS	Tertile	IV	0.083	0.379	.001	9	view →
SKCM	OS	Tertile	IV	0.415	0.861	.014	9	view →
LIHC	OS	Tertile	III,IV	0.312	0.748	.008	9	view →
LGG	DFS	Quartile	All	0.750	0.854	.004	7	view →
ESCA	OS	Tertile	III,IV	0.681	0.358	.049	6	view →
READ	OS	Tertile	III,IV	0.231	0.596	.017	6	view →
KIRC	DFS	Quartile	All	0.801	0.873	.049	2	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 12 lineages.

SPCS3-AS1–LUSC (OS)

Open the LUSC breakdown →