SPCS3-AS1

Across TCGA pan-cancer cohorts, SPCS3-AS1 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of SPCS3-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where SPCS3-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types SPCS3-AS1 is over-expressed in tumor, although a few such as KIRP and KIRC show the opposite, repressed pattern.

KIRP, KIRC, and LUAD are the cancer types where SPCS3-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SPCS3-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	II,III,IV	−0.305	<.001	7	view →
KIRC	All	All	−0.139	<.001	4	view →
LUAD	All	III,IV	+0.060	.021	4	view →
THCA	All	All	−0.056	.014	3	view →
UCEC	All	III,IV	+0.213	.046	2	view →
KICH	All	All	−0.156	.011	2	view →
COAD	Male	IV	−0.084	.044	1	view →
LUSC	All	All	−0.031	.043	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

SPCS3-AS1–KIRP

Open the KIRP breakdown →