SPC24

Across TCGA patient cohorts, SPC24 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPC24-associated genes across cancer lineages are MIR548AL, RNU6-80P, and PINCR. Each is linked with SPC24 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPC24-to-partner and partner-to-SPC24 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR548AL grouped by SPC24-low versus SPC24-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPC24→partner) and Y-score (partner→SPC24) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR548AL →	+0.363	+4.226	<.001	.008	3	1
UCEC	RNU6-80P →	+0.892	+4.298	<.001	.001	3	1
UCEC	PINCR →	+0.850	+3.600	<.001	.009	3	1
UCEC	TRDV3 →	+0.430	+3.831	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

MIR548AL by SPC24 expression — UCEC

Explore this box plot interactively →