SPATA48

Across TCGA patient cohorts, SPATA48 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,335 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible SPATA48-associated GO terms across cancer lineages are T cell receptor signaling pathway, Regulation of calcium ion transmembrane transport, and Positive regulation of lymphocyte differentiation. Each is linked with SPATA48 in more than 13 cancer types. Because this analysis shows association rather than direction, both SPATA48-to-partner and partner-to-SPATA48 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, T cell receptor signaling pathway grouped by SPATA48-low versus SPATA48-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPATA48→partner) and Y-score (partner→SPATA48) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	T cell receptor signaling pathway →	+0.064	+0.094	<.001	<.001	3	14
STAD	Regulation of calcium ion transmembrane transport →	+0.036	+0.105	<.001	<.001	3	13
STAD	Positive regulation of lymphocyte differentiation →	+0.064	+0.107	<.001	<.001	3	13
STAD	Regulation of alpha-beta T cell differentiation →	+0.056	+0.101	<.001	<.001	3	13
STAD	Lymphocyte homeostasis →	+0.071	+0.094	<.001	<.001	3	13
STAD	Leukocyte mediated cytotoxicity →	+0.051	+0.102	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,335 associations by consensus.

T cell receptor signaling pathway by SPATA48 expression — STAD

Explore this box plot interactively →