SPATA33

Across TCGA patient cohorts, SPATA33 mutation is significantly associated with the RNA expression of many other genes, with 59 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPATA33-associated genes across cancer lineages are MIR6515, RNU6-147P, and LINC02644. Each is linked with SPATA33 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPATA33-to-partner and partner-to-SPATA33 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6515 grouped by SPATA33-low versus SPATA33-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPATA33→partner) and Y-score (partner→SPATA33) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	MIR6515 →	+0.687	+7.640	<.001	.009	3	2
UCEC	RNU6-147P →	+0.674	+4.551	<.001	.009	3	2
UCEC	LINC02644 →	+0.368	+4.484	<.001	.009	3	2
UCEC	MTND3P5 →	+0.236	+4.256	.009	.008	3	2
UCEC	SNORD116-22 →	+0.586	+4.852	<.001	.006	3	1
UCEC	OR12D2 →	+0.058	+4.771	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 59 associations by consensus.

MIR6515 by SPATA33 expression — BLCA

Explore this box plot interactively →