SPATA33

Across TCGA pan-cancer cohorts, SPATA33 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated SPATA33 data layer compared with 1 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher SPATA33 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SPATA33 expression acts as an unfavorable survival marker, although some lineages such as UCEC and UVM show a favorable association.

ACC, LGG, and UCEC are the cancer types where SPATA33 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Tertile	II,III,IV	0.695	0.954	<.001	79	view →
LGG	OS	Median	All	0.723	0.895	<.001	53	view →
UCEC	OS	Tertile	All	0.791	0.537	.002	46	view →
SARC	DFS	Median	All	0.529	0.690	<.001	33	view →
LIHC	DFS	Quartile	All	0.433	0.636	<.001	27	view →
UVM	DFS	Quartile	III,IV	0.992	0.308	.004	22	view →
SCLC	DFS	Median	II,III,IV	0.494	0.214	.006	20	view →
THYM	OS	Quartile	All	1.000	0.515	.002	20	view →
KIRP	OS	Tertile	II,III,IV	0.958	0.753	.015	20	view →
BLCA	DFS	Tertile	IV	0.205	0.725	<.001	15	view →
LUSC	DFS	Median	III,IV	0.449	0.820	.027	13	view →
OV	DFS	Quartile	IV	0.544	0.339	.044	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

SPATA33–ACC (OS)

Open the ACC breakdown →