SPATA3

Across TCGA patient cohorts, SPATA3 mutation is significantly associated with the RNA expression of many other genes, with 106 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPATA3-associated genes across cancer lineages are LINC00869, ZNF215, and ZNF117. Each is linked with SPATA3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPATA3-to-partner and partner-to-SPATA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC00869 grouped by SPATA3-low versus SPATA3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPATA3→partner) and Y-score (partner→SPATA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LINC00869 →	-0.566	-3.636	<.001	.001	3	1
UCEC	ZNF215 →	+0.657	+2.595	.001	.006	3	1
UCEC	ZNF117 →	-0.817	-3.689	.001	.001	3	1
UCEC	SLC25A28 →	+0.350	+2.595	.007	.006	3	1
UCEC	WHAMM →	+0.411	+3.386	.004	.004	3	1
UCEC	NTAN1 →	+0.562	+3.483	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 106 associations by consensus.

LINC00869 by SPATA3 expression — UCEC

Explore this box plot interactively →