SPATA3

Across TCGA pan-cancer cohorts, SPATA3 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated SPATA3 data layer compared with 1 for mutation status.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher SPATA3 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SPATA3 expression acts as an unfavorable survival marker, although some lineages such as HNSC and PAAD show a favorable association.

BRCA, KIRC, and ACC are the cancer types where SPATA3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Tertile	II,III,IV	0.867	0.933	<.001	123	view →
KIRC	OS	Median	All	0.503	0.687	<.001	117	view →
ACC	OS	Tertile	All	0.193	0.820	<.001	69	view →
LGG	OS	Median	All	0.724	0.884	<.001	54	view →
SKCM	DFS	Tertile	All	0.596	0.757	<.001	45	view →
KICH	OS	Tertile	II,III,IV	0.093	0.841	<.001	39	view →
THYM	OS	Tertile	III,IV	0.212	0.953	.009	30	view →
LIHC	OS	Tertile	All	0.388	0.602	.001	24	view →
SARC	DFS	Tertile	All	0.123	0.375	<.001	21	view →
HNSC	OS	Quartile	IV	0.509	0.297	.008	20	view →
PAAD	OS	Tertile	II,III,IV	0.789	0.381	.015	19	view →
LUAD	DFS	Tertile	IV	0.342	0.893	<.001	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

SPATA3–BRCA (OS)

Open the BRCA breakdown →