SPATA3

Across TCGA pan-cancer cohorts, SPATA3 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of SPATA3’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where SPATA3 RNA is repressed in tumor relative to normal tissue. In most cancer types SPATA3 is over-expressed in tumor, although a few such as BRCA and KIRP show the opposite, repressed pattern.

BRCA, KIRP, and THCA are the cancer types where SPATA3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SPATA3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	All	III,IV	−0.058	.027	4	view →
KIRP	Male	All	−0.012	.032	1	view →
THCA	Female	II,III,IV	−0.010	.032	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

SPATA3–BRCA

Open the BRCA breakdown →