SPATA3

Across TCGA patient cohorts, SPATA3 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPATA3-associated genes across cancer lineages are A-Raf_pS299, Ku80, and PDK1_pS241. Each is linked with SPATA3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPATA3-to-partner and partner-to-SPATA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by SPATA3-low versus SPATA3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPATA3→partner) and Y-score (partner→SPATA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.160	-3.321	.010	.010	3	1
UCEC	Ku80 →	+0.255	+3.009	.039	.019	3	1
UCEC	PDK1_pS241 →	+0.230	+2.833	.010	.034	3	1
UCEC	AMPK_pT172 →	+0.594	+3.335	.005	.005	3	1
UCEC	VHL →	-1.030	-3.000	.003	.036	3	1
UCEC	p62 Lck ligand →	+0.492	+3.321	.003	.010	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

A-Raf_pS299 by SPATA3 expression — UCEC

Explore this box plot interactively →