SPATA3

Across TCGA cell cohorts, SPATA3 RNA expression is significantly associated with the go_rna of many other GO terms, with 384 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible SPATA3-associated GO terms across cancer lineages are DNA double-strand break processing involved in repair via single-strand annealing, Urinary bladder smooth muscle contraction, and Urinary tract smooth muscle contraction. Each is linked with SPATA3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPATA3-to-partner and partner-to-SPATA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA double-strand break processing involved in repair via single-strand annealing grouped by SPATA3-low versus SPATA3-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPATA3→partner) and Y-score (partner→SPATA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	DNA double-strand break processing involved in repair via single-strand annealing →	-0.064	-0.259	<.001	.003	3	2
BLOOD_Lymphoma	Urinary bladder smooth muscle contraction →	+0.928	+0.256	<.001	.003	3	2
BLOOD_Lymphoma	Urinary tract smooth muscle contraction →	+0.928	+0.256	<.001	.003	3	2
BLOOD_Lymphoma	Positive regulation of supramolecular fiber organization →	+0.030	+0.238	.004	.007	3	2
BLOOD_Lymphoma	Regulation of non-canonical Wnt signaling pathway →	+0.130	+0.270	<.001	.002	3	2
BLOOD_Lymphoma	Double-strand break repair via single-strand annealing →	-0.064	-0.259	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 384 associations by consensus.

DNA double-strand break processing involved in repair via single-strand annealing by SPATA3 expression — BLOOD_Lymphoma

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