SPATA2L

Across TCGA patient cohorts, SPATA2L mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPATA2L-associated genes across cancer lineages are A-Raf_pS299, p62 Lck ligand, and Rad50. Each is linked with SPATA2L in more than 1 cancer types. Because this analysis shows association rather than direction, both SPATA2L-to-partner and partner-to-SPATA2L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by SPATA2L-low versus SPATA2L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPATA2L→partner) and Y-score (partner→SPATA2L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.117	-2.584	.036	.011	3	1
UCEC	p62 Lck ligand →	+0.614	+1.884	<.001	.030	3	1
UCEC	Rad50 →	-0.317	-2.986	.004	.035	3	1
UCEC	TIGAR →	+0.176	+3.727	.013	<.001	3	1
UCEC	ASNS →	+0.525	+2.321	.001	.034	3	1
UCEC	Bid →	+0.143	+3.169	.010	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

A-Raf_pS299 by SPATA2L expression — UCEC

Explore this box plot interactively →