SPATA2L

Across TCGA pan-cancer cohorts, SPATA2L RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of SPATA2L’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where SPATA2L RNA is repressed in tumor relative to normal tissue. In most cancer types SPATA2L is over-expressed in tumor, although a few such as KICH and LUSC show the opposite, repressed pattern.

KICH, COAD, and HNSC are the cancer types where SPATA2L tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SPATA2L RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	III,IV	−1.681	<.001	9	view →
COAD	Male	All	+0.633	<.001	9	view →
HNSC	Male	III,IV	+0.959	<.001	8	view →
STAD	Male	II,III,IV	+1.219	<.001	6	view →
LUSC	All	II,III,IV	−0.739	<.001	5	view →
LIHC	All	III,IV	+0.671	.002	5	view →
LUAD	All	All	−0.422	<.001	3	view →
CHOL	All	All	+0.784	.002	2	view →
KIRP	All	IV	+0.672	.007	2	view →
UCEC	All	All	+0.603	.003	2	view →
READ	All	III,IV	+0.415	.036	2	view →
PRAD	All	All	+0.300	.010	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

SPATA2L–KICH

Open the KICH breakdown →