SPATA2L

Across TCGA cell cohorts, SPATA2L mutation is significantly associated with the drug of many other genes, with 14 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SPATA2L-associated genes across cancer lineages are Temsirolimus, Lestaurtinib, and 150412. Each is linked with SPATA2L in more than 1 cancer types. Because this analysis shows association rather than direction, both SPATA2L-to-partner and partner-to-SPATA2L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Temsirolimus grouped by SPATA2L-low versus SPATA2L-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPATA2L→partner) and Y-score (partner→SPATA2L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Temsirolimus →	+0.496	+2.649	.030	.046	2	1
LARGE_INTESTINE	Lestaurtinib →	+0.663	+2.710	.006	.043	2	1
LARGE_INTESTINE	150412 →	+0.497	+3.000	.001	.017	2	1
LARGE_INTESTINE	Dactinomycin →	+0.596	+2.649	.038	.046	2	1
LARGE_INTESTINE	SU11274 →	+0.497	+2.874	.010	.021	2	1
LARGE_INTESTINE	Cytarabine →	+0.820	+2.655	.034	.044	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

Temsirolimus by SPATA2L expression — LARGE_INTESTINE

Explore this box plot interactively →