SPART

Across TCGA cell cohorts, SPART mutation is significantly associated with the RNA expression of many other genes, with 83 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SPART-associated genes across cancer lineages are USP29, C20orf85, and HAO1. Each is linked with SPART in more than 1 cancer types. Because this analysis shows association rather than direction, both SPART-to-partner and partner-to-SPART results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, USP29 grouped by SPART-low versus SPART-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPART→partner) and Y-score (partner→SPART) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	USP29 →	+0.009	+4.078	<.001	.009	3	2
BLOOD_Leukemia	C20orf85 →	+0.029	+4.384	<.001	.006	3	2
BREAST	HAO1 →	+0.038	+3.378	.005	.006	3	1
BREAST	SNTG1 →	+0.205	+3.070	<.001	.009	3	1
BREAST	SLC38A11 →	+0.659	+3.628	.001	.009	3	1
BREAST	OR5M3 →	+0.015	+3.781	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 83 associations by consensus.

USP29 by SPART expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →