SPART

Across TCGA pan-cancer cohorts, SPART RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of SPART’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where SPART RNA is repressed in tumor relative to normal tissue. In most cancer types SPART is over-expressed in tumor, although a few such as COAD and LUAD show the opposite, repressed pattern.

COAD, LUAD, and THCA are the cancer types where SPART tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SPART RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	II,III,IV	−1.233	<.001	11	view →
LUAD	Female	II,III,IV	−0.998	<.001	11	view →
THCA	Male	III,IV	−0.958	<.001	10	view →
KICH	Female	II,III,IV	−1.985	<.001	9	view →
LUSC	Female	II,III,IV	−1.327	<.001	9	view →
BLCA	Male	All	−1.462	<.001	8	view →
UCEC	All	All	−1.583	<.001	6	view →
BRCA	All	III,IV	−0.943	<.001	6	view →
KIRC	All	All	+0.297	<.001	6	view →
STAD	All	All	−1.123	<.001	5	view →
LIHC	Male	All	−0.874	<.001	3	view →
READ	Female	All	−2.405	.003	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

SPART–COAD

Open the COAD breakdown →