Across TCGA patient cohorts, SPANXN3 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPANXN3-associated genes across cancer lineages are EGFR_pY1068, MEK1, and MSH2. Each is linked with SPANXN3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPANXN3-to-partner and partner-to-SPANXN3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPANXN3→partner) and Y-score (partner→SPANXN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.317	-3.459	.006	.005	3	1
UCEC	MEK1 →	+0.391	+3.321	.021	.010	3	1
UCEC	MSH2 →	-0.335	-2.973	.001	.035	3	1
UCEC	N-Ras →	-0.112	-3.687	.043	.001	3	1
UCEC	p21 →	+0.288	+2.584	.001	.011	3	1
UCEC	p62 Lck ligand →	+0.347	+2.817	.022	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

Exploration

SPANXN3 survival (RNA) · tumor vs normal (RNA) · all SPANXN3 data types