Across TCGA patient cohorts, SPANXC mutation is significantly associated with the RNA expression of many other genes, with 54 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible SPANXC-associated genes across cancer lineages are IGKV2OR2-1, MTRNR2L2, and RN7SL680P. Each is linked with SPANXC in more than 1 cancer types. Because this analysis shows association rather than direction, both SPANXC-to-partner and partner-to-SPANXC results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPANXC→partner) and Y-score (partner→SPANXC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IGKV2OR2-1 →	+0.799	+3.841	<.001	.005	3	1
UCEC	MTRNR2L2 →	+1.020	+3.867	<.001	.004	3	1
SKCM	RN7SL680P →	+0.189	+5.219	<.001	.002	3	1
SKCM	LINC00251 →	+0.019	+4.797	<.001	.003	3	1
SKCM	BCRP5 →	+0.310	+3.692	.004	.007	3	1
SKCM	SPATA31D5P →	+0.015	+3.796	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

Exploration

SPANXC survival (RNA) · tumor vs normal (RNA) · all SPANXC data types