Across TCGA pan-cancer cohorts, SPANXC RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of SPANXC’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SPANXC RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SPANXC is over-expressed in tumor.

HNSC, LUSC, and LUAD are the cancer types where SPANXC tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SPANXC RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	II,III,IV	+0.623	.001	9	view →
LUSC	All	All	+0.235	.025	2	view →
LUAD	Female	All	+0.047	.029	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: SPANXC RNA expression & survival · all SPANXC data types