SPAG5

Across TCGA patient cohorts, SPAG5 mutation is significantly associated with the RNA expression of many other genes, with 3,470 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPAG5-associated genes across cancer lineages are RNU6-207P, RNU4-85P, and PGBD4P2. Each is linked with SPAG5 in more than 2 cancer types. Because this analysis shows association rather than direction, both SPAG5-to-partner and partner-to-SPAG5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-207P grouped by SPAG5-low versus SPAG5-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPAG5→partner) and Y-score (partner→SPAG5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU6-207P →	+0.127	+3.325	<.001	.004	3	3
COAD	RNU4-85P →	+0.235	+3.092	<.001	.003	3	3
LUSC	PGBD4P2 →	+0.406	+5.309	<.001	.003	3	2
READ	MIR6816 →	+0.578	+6.681	<.001	<.001	3	2
KIRP	PRR13P7 →	+0.089	+4.016	<.001	.004	3	2
UCEC	ZNF285 →	-0.414	-1.877	.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,470 associations by consensus.

RNU6-207P by SPAG5 expression — SKCM

Explore this box plot interactively →