SPAG5

Across TCGA pan-cancer cohorts, SPAG5 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of SPAG5’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SPAG5 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SPAG5 is over-expressed in tumor, although a few such as THCA and KIRP show the opposite, repressed pattern.

HNSC, BLCA, and LUAD are the cancer types where SPAG5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SPAG5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	+2.260	<.001	12	view →
BLCA	Male	IV	+3.357	<.001	11	view →
LUAD	Male	III,IV	+3.166	<.001	11	view →
THCA	Male	III,IV	−1.957	<.001	11	view →
COAD	Male	II,III,IV	+1.102	<.001	10	view →
STAD	Female	All	+2.719	<.001	9	view →
LIHC	Male	All	+1.329	<.001	9	view →
LUSC	Female	All	+3.354	<.001	8	view →
UCEC	All	III,IV	+3.284	<.001	8	view →
KIRP	Male	All	−1.435	<.001	8	view →
BRCA	All	III,IV	+2.444	<.001	6	view →
KICH	Female	All	−2.052	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

SPAG5–HNSC

Open the HNSC breakdown →