SPAG17

Across TCGA patient cohorts, SPAG17 mutation is significantly associated with the RNA expression of many other genes, with 6,015 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPAG17-associated genes across cancer lineages are NSL1, TYMS, and TYMSOS. Each is linked with SPAG17 in more than 6 cancer types. Because this analysis shows association rather than direction, both SPAG17-to-partner and partner-to-SPAG17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NSL1 grouped by SPAG17-low versus SPAG17-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPAG17→partner) and Y-score (partner→SPAG17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	NSL1 →	+0.388	+3.472	.003	.002	2	7
UCEC	TYMS →	+0.713	+1.485	<.001	<.001	3	6
COAD	TYMSOS →	+0.751	+2.392	<.001	<.001	3	6
UCEC	MRPS15 →	+0.334	+1.506	<.001	<.001	3	6
STAD	MASTL →	+0.492	+2.618	.007	.005	3	6
LUAD	SUV39H2 →	+0.428	+2.321	.002	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,015 associations by consensus.

NSL1 by SPAG17 expression — COAD

Explore this box plot interactively →