SPAG17

Across TCGA pan-cancer cohorts, SPAG17 RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated SPAG17 data layer compared with 11 for mutation status.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher SPAG17 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated SPAG17 expression acts as an unfavorable survival marker, although some lineages such as ACC and READ show a favorable association.

ACC, DLBC, and LGG are the cancer types where SPAG17 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.706	0.225	<.001	76	view →
DLBC	OS	Quartile	All	0.163	1.000	.006	61	view →
LGG	DFS	Median	All	0.298	0.507	<.001	53	view →
KIRC	DFS	Median	All	0.510	0.725	.001	35	view →
READ	OS	Median	All	0.979	0.855	.002	26	view →
UCS	DFS	Median	IV	0.909	0.416	.008	24	view →
UCEC	DFS	Median	All	0.801	0.875	.011	24	view →
BRCA	OS	Median	IV	0.775	0.315	.001	20	view →
CHOL	DFS	Tertile	All	0.676	0.086	.003	18	view →
BLCA	DFS	Median	All	0.679	0.568	.006	18	view →
MESO	OS	Median	IV	0.863	0.328	.001	12	view →
UVM	OS	Quartile	III,IV	0.418	1.000	.026	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

SPAG17–ACC (DFS)

Open the ACC breakdown →