SPAG11A

Across TCGA cell cohorts, SPAG11A mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible SPAG11A-associated genes across cancer lineages are PZP, GDF3, and OR2AK2. Each is linked with SPAG11A in more than 1 cancer types. Because this analysis shows association rather than direction, both SPAG11A-to-partner and partner-to-SPAG11A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PZP grouped by SPAG11A-low versus SPAG11A-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPAG11A→partner) and Y-score (partner→SPAG11A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PZP →	+0.061	+4.044	<.001	.009	3	1
LUNG_SCLC	GDF3 →	+0.010	+4.643	<.001	.004	3	1
LUNG_SCLC	OR2AK2 →	+0.123	+4.269	<.001	.005	3	1
LUNG_SCLC	OR2L5 →	+0.052	+4.269	<.001	.005	3	1
LUNG_SCLC	OR2L3 →	+0.069	+4.523	<.001	.003	3	1
LUNG_SCLC	OR6J1 →	+0.033	+4.044	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

PZP by SPAG11A expression — LUNG_SCLC

Explore this box plot interactively →