SPAG11A

Across TCGA pan-cancer cohorts, SPAG11A RNA is linked to patient survival in 16 of 34 cancer types, making it the most broadly survival-associated SPAG11A data layer compared with 3 for mutation status.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher SPAG11A RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SPAG11A expression acts as an unfavorable survival marker, although some lineages such as BLCA and THCA show a favorable association.

KIRC, UCS, and KICH are the cancer types where SPAG11A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Tertile	III,IV	0.222	0.518	<.001	144	view →
UCS	DFS	Tertile	All	0.166	0.495	.002	96	view →
KICH	OS	Tertile	III,IV	0.178	0.847	<.001	69	view →
SKCM	DFS	Tertile	All	0.387	0.632	<.001	69	view →
UVM	OS	Tertile	All	0.136	0.919	<.001	63	view →
MESO	OS	Tertile	All	0.217	0.583	<.001	54	view →
BLCA	OS	Tertile	II,III,IV	0.809	0.403	.009	48	view →
PAAD	OS	Tertile	All	0.150	0.596	<.001	36	view →
THCA	DFS	Tertile	All	0.938	0.795	.003	27	view →
ESCA	DFS	Tertile	All	0.410	0.570	.009	27	view →
ACC	OS	Tertile	IV	0.327	0.633	.045	18	view →
STAD	DFS	Tertile	IV	0.083	0.379	.001	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 16 lineages.

SPAG11A–KIRC (DFS)

Open the KIRC breakdown →