SPACA3

Across TCGA patient cohorts, SPACA3 mutation is significantly associated with the RNA expression of many other genes, with 1,803 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPACA3-associated genes across cancer lineages are OIP5, PARP2, and RNU6-1213P. Each is linked with SPACA3 in more than 2 cancer types. Because this analysis shows association rather than direction, both SPACA3-to-partner and partner-to-SPACA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OIP5 grouped by SPACA3-low versus SPACA3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPACA3→partner) and Y-score (partner→SPACA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	OIP5 →	+0.777	+3.269	.001	<.001	3	3
UCEC	PARP2 →	+0.553	+4.048	<.001	<.001	3	3
UCEC	RNU6-1213P →	+0.165	+3.292	<.001	.003	3	3
LGG	USP9YP10 →	+0.049	+7.977	<.001	.007	3	2
SKCM	MTHFD1L →	+0.641	+3.340	.007	.005	3	2
UCEC	HAUS2 →	+0.690	+3.247	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,803 associations by consensus.

OIP5 by SPACA3 expression — UCEC

Explore this box plot interactively →