SPACA3

Across TCGA pan-cancer cohorts, SPACA3 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of SPACA3’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where SPACA3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SPACA3 is over-expressed in tumor, although a few such as UCEC and KICH show the opposite, repressed pattern.

COAD, UCEC, and LUAD are the cancer types where SPACA3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SPACA3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	All	+0.982	<.001	7	view →
UCEC	All	All	−0.276	<.001	6	view →
LUAD	All	II,III,IV	+0.410	.005	4	view →
KICH	All	All	−0.044	.008	4	view →
READ	Female	All	+0.923	.010	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

SPACA3–COAD

Open the COAD breakdown →