SPACA1

Across TCGA patient cohorts, SPACA1 protein abundance is significantly associated with the RNA expression of many other genes, with 758 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPACA1-associated genes across cancer lineages are DDR2, RNU4-53P, and DICER1. Each is linked with SPACA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPACA1-to-partner and partner-to-SPACA1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SPACA1 versus DDR2 in BRCA, with a Pearson correlation of -0.81.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPACA1→partner) and Y-score (partner→SPACA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	DDR2 →	-0.979	-0.880	.006	<.001	3	2
LSCC	RNU4-53P →	+1.085	+0.497	.005	.005	3	2
UCEC	DICER1 →	+0.276	+0.474	.007	.004	3	1
UCEC	PPP4R3A →	+0.332	+0.549	<.001	<.001	3	1
UCEC	PLCB4 →	+0.495	+0.462	.004	<.001	3	1
UCEC	SALL1 →	+0.821	+0.560	.006	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 758 associations by consensus.

SPACA1 vs DDR2 — BRCA

Explore this scatter interactively →