SPACA1

Across TCGA pan-cancer cohorts, SPACA1 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of SPACA1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where SPACA1 RNA is repressed in tumor relative to normal tissue. In most cancer types SPACA1 is over-expressed in tumor, although a few such as KIRC show the opposite, repressed pattern.

KIRC, LIHC, and LUSC are the cancer types where SPACA1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SPACA1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	−0.133	<.001	4	view →
LIHC	All	All	+0.093	.013	3	view →
LUSC	Male	All	+0.009	.042	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

SPACA1–KIRC

Open the KIRC breakdown →