SOX5

Across TCGA patient cohorts, SOX5 mutation is significantly associated with the RNA expression of many other genes, with 5,692 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SOX5-associated genes across cancer lineages are MRPL16, PSMA4, and BLOC1S2. Each is linked with SOX5 in more than 4 cancer types. Because this analysis shows association rather than direction, both SOX5-to-partner and partner-to-SOX5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRPL16 grouped by SOX5-low versus SOX5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SOX5→partner) and Y-score (partner→SOX5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MRPL16 →	+0.295	+1.934	.001	.002	3	5
COAD	PSMA4 →	+0.543	+2.807	<.001	.003	3	5
COAD	BLOC1S2 →	+0.603	+2.807	<.001	.003	3	4
UCEC	CDCA4 →	+0.424	+3.264	.002	<.001	3	4
UCEC	TYMSOS →	+0.864	+2.254	<.001	<.001	3	4
UCEC	DNAJC9 →	+0.649	+1.968	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,692 associations by consensus.

MRPL16 by SOX5 expression — UCEC

Explore this box plot interactively →