SOX5

Across TCGA pan-cancer cohorts, SOX5 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of SOX5’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where SOX5 RNA is repressed in tumor relative to normal tissue. In most cancer types SOX5 is over-expressed in tumor, although a few such as LUAD and THCA show the opposite, repressed pattern.

LUAD, THCA, and COAD are the cancer types where SOX5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SOX5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	III,IV	−1.201	<.001	11	view →
THCA	Male	II,III,IV	−1.023	<.001	11	view →
COAD	Male	All	−0.443	<.001	11	view →
KIRC	Male	II,III,IV	−0.572	<.001	10	view →
BLCA	Male	All	−1.183	<.001	8	view →
LUSC	Female	II,III,IV	−1.158	<.001	8	view →
BRCA	All	III,IV	−1.135	<.001	6	view →
CHOL	Female	All	−2.096	<.001	5	view →
STAD	All	All	−0.549	.004	5	view →
KICH	Male	III,IV	−1.004	.025	2	view →
KIRP	Male	All	−0.704	<.001	2	view →
READ	All	All	−0.588	.003	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

SOX5–LUAD

Open the LUAD breakdown →