SOX2

Across TCGA patient cohorts, SOX2 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SOX2-associated genes across cancer lineages are STAT3_pY705, ATM, and 4E-BP1. Each is linked with SOX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SOX2-to-partner and partner-to-SOX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by SOX2-low versus SOX2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SOX2→partner) and Y-score (partner→SOX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.376	-2.502	<.001	.002	3	2
UCEC	ATM →	-0.640	-2.807	<.001	.003	3	2
UCEC	4E-BP1 →	+0.396	+3.489	<.001	.002	3	2
UCEC	C-Raf →	+0.237	+2.584	<.001	.010	3	2
COAD	PDCD4 →	-0.571	-2.991	.008	.036	3	2
UCEC	14-3-3_beta →	-0.120	-3.432	.002	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

STAT3_pY705 by SOX2 expression — UCEC

Explore this box plot interactively →