SOX2-OT

Across TCGA pan-cancer cohorts, SOX2-OT RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated SOX2-OT data layer.

The strongest signal is observed in mesothelioma (MESO), where higher SOX2-OT RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated SOX2-OT expression acts as an unfavorable survival marker, although some lineages such as MESO and LUSC show a favorable association.

MESO, LUSC, and UVM are the cancer types where SOX2-OT RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	DFS	Tertile	All	0.888	0.240	.001	38	view →
LUSC	OS	Quartile	All	0.838	0.712	.001	36	view →
UVM	OS	Median	III,IV	0.240	0.836	.001	33	view →
SKCM	OS	Median	III,IV	0.609	0.226	.001	26	view →
LUAD	DFS	Tertile	All	0.492	0.183	.009	22	view →
READ	OS	Median	III,IV	1.000	0.799	.004	19	view →
KIRP	DFS	Tertile	All	1.000	0.787	.017	18	view →
COAD	DFS	Median	All	0.399	0.653	.028	11	view →
LIHC	OS	Quartile	III,IV	0.686	0.397	.012	9	view →
CESC	OS	Median	All	0.916	0.826	.016	8	view →
ESCA	OS	Median	All	1.000	0.693	.038	6	view →
BLCA	DFS	Median	IV	0.288	0.590	.004	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

SOX2-OT–MESO (DFS)

Open the MESO breakdown →