SOX2-OT

Across TCGA pan-cancer cohorts, SOX2-OT RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of SOX2-OT’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where SOX2-OT RNA is repressed in tumor relative to normal tissue. In most cancer types SOX2-OT is over-expressed in tumor, although a few such as KIRP and KIRC show the opposite, repressed pattern.

KIRP, KIRC, and HNSC are the cancer types where SOX2-OT tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SOX2-OT RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	Male	II,III,IV	−0.225	<.001	11	view →
KIRC	Female	II,III,IV	−0.271	<.001	9	view →
HNSC	All	II,III,IV	+0.531	.006	8	view →
THCA	Male	III,IV	−0.247	<.001	8	view →
LUSC	Female	All	+1.378	<.001	6	view →
KICH	Male	All	−0.269	<.001	6	view →
STAD	Male	II,III,IV	−0.108	.009	5	view →
BRCA	All	All	+0.086	.001	4	view →
READ	Female	All	−0.208	.030	2	view →
CHOL	All	All	+0.164	.024	2	view →
PRAD	All	All	−0.068	.035	2	view →
LIHC	All	All	+0.054	.008	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

SOX2-OT–KIRP

Open the KIRP breakdown →