SOX17

Across TCGA cell cohorts, SOX17 mutation is significantly associated with the RNA expression of many other genes, with 85 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SOX17-associated genes across cancer lineages are OR2AJ1, KRTAP9-1, and ARL1. Each is linked with SOX17 in more than 1 cancer types. Because this analysis shows association rather than direction, both SOX17-to-partner and partner-to-SOX17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2AJ1 grouped by SOX17-low versus SOX17-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SOX17→partner) and Y-score (partner→SOX17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	OR2AJ1 →	+0.042	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	KRTAP9-1 →	+0.053	+6.247	<.001	<.001	3	1
LARGE_INTESTINE	ARL1 →	+0.599	+3.502	<.001	.001	3	1
LARGE_INTESTINE	ZNF644 →	+0.540	+3.502	<.001	.001	3	1
LARGE_INTESTINE	PGM3 →	+0.728	+3.067	.007	.009	3	1
LARGE_INTESTINE	GTF2B →	+0.459	+3.082	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 85 associations by consensus.

OR2AJ1 by SOX17 expression — BLOOD_Lymphoma

Explore this box plot interactively →