SOX17

Across TCGA pan-cancer cohorts, SOX17 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of SOX17’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where SOX17 RNA is repressed in tumor relative to normal tissue. In most cancer types SOX17 is over-expressed in tumor, although a few such as LUAD and BLCA show the opposite, repressed pattern.

LUAD, BLCA, and KICH are the cancer types where SOX17 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SOX17 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	III,IV	−2.636	<.001	11	view →
BLCA	Male	All	−2.604	<.001	11	view →
KICH	Male	All	−2.385	<.001	11	view →
KIRP	Female	All	−1.560	<.001	9	view →
LUSC	Female	II,III,IV	−2.875	<.001	8	view →
LIHC	All	II,III,IV	+0.640	<.001	8	view →
UCEC	All	All	+2.243	<.001	6	view →
BRCA	All	II,III,IV	−1.847	<.001	6	view →
COAD	All	All	−0.513	.002	5	view →
STAD	Female	All	−1.544	.027	2	view →
PRAD	All	All	−0.506	.016	2	view →
READ	Female	All	−1.140	.029	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

SOX17–LUAD

Open the LUAD breakdown →