SOX14

Across TCGA patient cohorts, SOX14 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,317 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible SOX14-associated GO terms across cancer lineages are Negative regulation of protein exit from endoplasmic reticulum, Maintenance of DNA repeat elements, and Positive regulation of mitotic cell cycle. Each is linked with SOX14 in more than 9 cancer types. Because this analysis shows association rather than direction, both SOX14-to-partner and partner-to-SOX14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of protein exit from endoplasmic reticulum grouped by SOX14-low versus SOX14-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SOX14→partner) and Y-score (partner→SOX14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Negative regulation of protein exit from endoplasmic reticulum →	+0.050	+0.512	<.001	<.001	3	9
TGCT	Maintenance of DNA repeat elements →	+0.065	+0.205	<.001	<.001	3	9
HNSC	Positive regulation of mitotic cell cycle →	+0.024	+0.495	<.001	<.001	3	9
ESCA	Regulation of cell cycle G2/M phase transition →	+0.057	+0.501	<.001	.004	2	10
ESCA	Spindle localization →	+0.055	+0.426	<.001	.001	2	9
TGCT	Ventricular septum morphogenesis →	+0.042	+0.190	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,317 associations by consensus.

Negative regulation of protein exit from endoplasmic reticulum by SOX14 expression — ESCA

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