SOX14

Across TCGA pan-cancer cohorts, SOX14 RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated SOX14 data layer compared with 3 for mutation status.

The strongest signal is observed in uveal melanoma (UVM), where higher SOX14 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SOX14 expression acts as an unfavorable survival marker, although some lineages such as OV and UCEC show a favorable association.

UVM, OV, and UCEC are the cancer types where SOX14 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	All	0.428	0.761	.021	66	view →
OV	DFS	Tertile	All	0.458	0.358	.015	36	view →
UCEC	DFS	Quartile	II,III,IV	0.901	0.792	.006	30	view →
LIHC	OS	Tertile	All	0.640	0.805	.006	27	view →
DLBC	OS	Tertile	III,IV	0.175	0.874	.025	27	view →
STAD	DFS	Median	IV	0.500	0.137	.007	25	view →
GBM	DFS	Tertile	All	0.365	0.211	.022	18	view →
SCLC	OS	Quartile	II,III,IV	0.695	0.324	.021	15	view →
THYM	OS	Tertile	All	0.889	1.000	.017	14	view →
PAAD	DFS	Tertile	II,III,IV	0.602	0.384	.021	12	view →
LAML	DFS	Tertile	All	0.298	0.520	.030	12	view →
LUSC	OS	Tertile	III,IV	0.178	0.685	.012	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

SOX14–UVM (DFS)

Open the UVM breakdown →