SOX14

Across TCGA pan-cancer cohorts, SOX14 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of SOX14’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where SOX14 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SOX14 is over-expressed in tumor, although a few such as THCA and HNSC show the opposite, repressed pattern.

COAD, THCA, and STAD are the cancer types where SOX14 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SOX14 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	IV	+2.341	<.001	10	view →
THCA	All	II,III,IV	−0.070	<.001	9	view →
STAD	All	All	+0.751	.004	5	view →
HNSC	Female	All	−0.092	.001	3	view →
UCEC	All	All	+0.657	.001	2	view →
PRAD	All	All	+0.632	.015	2	view →
READ	Female	All	+0.284	.015	2	view →
KIRP	Male	All	−0.008	.034	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

SOX14–COAD

Open the COAD breakdown →