SOX14

Across TCGA patient cohorts, SOX14 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SOX14-associated genes across cancer lineages are EGFR_pY1068, Rab25, and STAT3_pY705. Each is linked with SOX14 in more than 1 cancer types. Because this analysis shows association rather than direction, both SOX14-to-partner and partner-to-SOX14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by SOX14-low versus SOX14-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SOX14→partner) and Y-score (partner→SOX14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.240	-3.169	.048	.019	3	1
UCEC	Rab25 →	-0.328	-2.459	.040	.020	3	1
UCEC	STAT3_pY705 →	-0.445	-2.459	<.001	.020	3	1
UCEC	CD49b →	-0.284	-2.446	.039	.020	3	1
UCEC	Cyclin-E1 →	+0.432	+2.459	.039	.020	3	1
UCEC	INPP4B →	-0.381	-3.169	.014	.019	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

EGFR_pY1068 by SOX14 expression — UCEC

Explore this box plot interactively →