SOS1-IT1

Across TCGA patient cohorts, SOS1-IT1 RNA expression is significantly associated with the protein abundance of many other proteins, with 14,332 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SOS1-IT1-associated proteins across cancer lineages are PSIP1, HNRNPLL, and NELFCD. Each is linked with SOS1-IT1 in more than 4 cancer types. Because this analysis shows association rather than direction, both SOS1-IT1-to-partner and partner-to-SOS1-IT1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SOS1-IT1 versus PSIP1 in HNSC, with a Pearson correlation of 0.41.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SOS1-IT1→partner) and Y-score (partner→SOS1-IT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PSIP1 →	+0.495	+0.789	<.001	<.001	3	5
LSCC	HNRNPLL →	+0.250	+0.762	<.001	<.001	3	5
LSCC	NELFCD →	+0.279	+0.640	<.001	<.001	3	5
GBM	NRF1 →	+0.391	+0.519	<.001	<.001	3	5
HNSC	TOP2B →	+0.325	+0.758	<.001	<.001	3	5
LSCC	PTBP2 →	+0.877	+0.467	.002	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,332 associations by consensus.

SOS1-IT1 vs PSIP1 — HNSC

Explore this scatter interactively →