SOS1-IT1

Across TCGA pan-cancer cohorts, SOS1-IT1 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of SOS1-IT1’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where SOS1-IT1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SOS1-IT1 is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.

LIHC, THCA, and HNSC are the cancer types where SOS1-IT1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SOS1-IT1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	Male	II,III,IV	+1.035	<.001	9	view →
THCA	Male	III,IV	−0.832	<.001	9	view →
HNSC	All	II,III,IV	+0.385	<.001	8	view →
LUSC	Male	II,III,IV	+0.878	<.001	7	view →
STAD	All	II,III,IV	+0.614	<.001	7	view →
LUAD	All	All	+0.430	.001	3	view →
CHOL	All	All	+0.892	<.001	2	view →
UCEC	All	II,III,IV	+0.711	.016	2	view →
BLCA	All	All	+0.482	.021	2	view →
KIRC	Male	III,IV	−0.234	.021	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

SOS1-IT1–LIHC

Open the LIHC breakdown →