SOS1-IT1

Across TCGA pan-cancer cohorts, SOS1-IT1 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated SOS1-IT1 data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher SOS1-IT1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SOS1-IT1 expression acts as an unfavorable survival marker, although some lineages such as OV and SARC show a favorable association.

UVM, UCEC, and ACC are the cancer types where SOS1-IT1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Quartile	III,IV	0.125	0.922	<.001	126	view →
UCEC	DFS	Tertile	All	0.515	0.742	<.001	86	view →
ACC	DFS	Median	All	0.487	0.826	<.001	66	view →
LGG	OS	Median	All	0.756	0.865	<.001	35	view →
LIHC	DFS	Quartile	III,IV	0.152	0.467	.001	20	view →
OV	OS	Quartile	II,III,IV	0.443	0.293	.005	18	view →
CESC	DFS	Tertile	II,III,IV	0.696	0.867	.018	16	view →
COAD	DFS	Tertile	All	0.563	0.770	.004	15	view →
BLCA	DFS	Tertile	All	0.473	0.711	.011	14	view →
KICH	OS	Tertile	II,III,IV	0.554	0.883	.030	13	view →
BRCA	OS	Quartile	III,IV	0.865	0.945	.019	12	view →
SARC	DFS	Median	All	0.709	0.546	.012	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

SOS1-IT1–UVM (DFS)

Open the UVM breakdown →