SORL1

Across TCGA cell cohorts, SORL1 mutation is significantly associated with the RNA expression of many other genes, with 774 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SORL1-associated genes across cancer lineages are CNBP, OR2A5, and CT83. Each is linked with SORL1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SORL1-to-partner and partner-to-SORL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CNBP grouped by SORL1-low versus SORL1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SORL1→partner) and Y-score (partner→SORL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CNBP →	+0.275	+2.614	.006	.003	3	3
STOMACH	OR2A5 →	+0.035	+3.217	<.001	.001	3	2
BREAST	CT83 →	+2.239	+3.777	.002	.001	3	2
SKIN	CNKSR2 →	+0.652	+3.502	.005	.001	3	2
LARGE_INTESTINE	UST →	+1.517	+3.743	<.001	<.001	3	2
BLOOD_Leukemia	RAB3GAP1 →	+0.488	+2.614	.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 774 associations by consensus.

CNBP by SORL1 expression — BLOOD_Leukemia

Explore this box plot interactively →