SORL1

Across TCGA pan-cancer cohorts, SORL1 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated SORL1 data layer compared with 11 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher SORL1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SORL1 expression acts as an unfavorable survival marker, although some lineages such as KIRC and ACC show a favorable association.

UVM, KIRC, and ACC are the cancer types where SORL1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.390	0.764	<.001	146	view →
KIRC	DFS	Median	All	0.719	0.543	<.001	129	view →
ACC	OS	Median	II,III,IV	0.895	0.616	<.001	74	view →
SKCM	OS	Tertile	All	0.426	0.223	<.001	70	view →
HNSC	OS	Tertile	All	0.417	0.752	<.001	63	view →
LIHC	OS	Median	III,IV	0.740	0.349	<.001	44	view →
LAML	DFS	Tertile	All	0.540	0.284	.003	42	view →
LUAD	OS	Quartile	III,IV	0.827	0.546	.001	22	view →
THYM	DFS	Median	All	0.951	0.788	.001	20	view →
COAD	OS	Median	IV	0.724	0.376	.011	19	view →
CHOL	DFS	Median	All	0.714	0.125	.002	15	view →
LUSC	OS	Tertile	All	0.823	0.696	.008	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

SORL1–UVM (DFS)

Open the UVM breakdown →